Effect of porcine reproductive and respiratory syndrome virus (PRRSV) exposure dose on fetal infection in vaccinated and nonvaccinated swine
نویسنده
چکیده
Method: Fifteen nonpregnant gilts obtained from a PRRS-free herd were vaccinated twice with a modified-live PRRSV vaccine prior to artificial insemination. At 90 days of gestation, these VACC-CHAL gilts and 16 pregnant, nonvaccinated CHAL sows were randomly allotted to one of four experimental groups: a control group that received a sham inoculation, or to groups that received a “low” (102 CCID50), “middle” (104 CCID50), or “high” (106 CCID50) dose of an intramuscular challenge of the NADC-8 PRRSV strain.
منابع مشابه
Porcine circovirus type 2 infection decreases the efficacy of a modified live porcine reproductive and respiratory syndrome virus vaccine.
Porcine reproductive and respiratory syndrome virus (PRRSV)-induced pneumonia is a major problem, and vaccination is used to reduce losses associated with PRRSV. Porcine circovirus type 2 (PCV2) causes lymphoid depletion, and there is concern that this adversely affects the immune response. The objective of this study was to investigate the effect of PCV2 infection on the efficacy of modified l...
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The live chimeric porcine circovirus type 2 (PCV2) vaccine with the capsid gene of the emerging subtype 2b cloned in the genomic backbone of the nonpathogenic PCV1 is attenuated in vivo and induces protective immunity against PCV2. To further determine the safety and efficacy of this experimental vaccine, we tested for evidence of pig-to-pig transmission by commingling nonvaccinated and vaccina...
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Introduction Porcine reproductive and respiratory syndrome (PRRS) costs the US pork industry $1.8 million per day.1 Swine practitioners have been successful eliminating PRRS virus (PRRSv) from breeding herds by implementing herd closure-homogenization protocols.2 Implementation of these protocols has resulted in a source of PRRSv PCR-negative weaned pigs to be placed in growing facilities. A la...
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NADC30-like porcine reproductive and respiratory syndrome virus (PRRSV) has widely spread in China and become locally dominant virus strain in some provinces. Although they are not pathogenic as highly pathogenic PRRSV (HP-RRRSV) that outbreaks since 2006, NADC30-like PRRSVs distinguished themselves by high incidence of recombination with other virus strains which lead to change of virulence. T...
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Control of porcine reproductive and respiratory syndrome (PRRS) is economically important for the swine industry worldwide. As current PRRS vaccines do not completely protect against heterologous challenge, alternative means of control, including enhanced genetic resilience, are needed. For reproductive PRRS, the genetic basis of fetal response to PRRS virus (PRRSV) infection is poorly understo...
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